Micro-computed tomography (micro-CT) produces high-resolution morphologic images that have been proved to be particularly useful for imaging of small animals. Furthermore, it is necessary to implement minimally invasive in vivo imaging technologies in order continuously to retain a smaller number of animals for experimentation. In a study, it is preferable to employ only a small number of experimental animals, particularly when there are concerns over budgets and over the welfare of the animals. The development of various animal disease models and the clinical simulations of pathologic conditions are necessary for the development of new diagnostic and therapeutic tools. Therefore, it is unlikely that the measured doses for the CT scans caused any radiation damage in the mice. No significant radiation effects were observed in the weight gain curves, organ weights, blood analyses, litter sizes, reared offspring sizes, and the histopathologic results. The total average dose at the center of the phantom during the 4-week scanning period was 194.3 mGy. ![]() The average X-ray dose of a CT scan measures 16.19 mGy at the center of a phantom and 16.24 mGy at an offset position of 7.5 mm from the center of the phantom. Although a scanning frequency of three scans per week is higher than that necessary for conventional studies, this study represents particular cases where the subjects may undergo an extreme number of examinations. Long-term in vivo whole-body micro-CT scans of ICR mice were performed for a duration of 4 weeks. In this study, we evaluated the biological radiation effects of measured radiation doses in ICR mice using cone-beam micro-CT scans. ![]() However, the correlations between the biological effects and the radiation doses have never been thoroughly evaluated in the majority of cases. Studies show that the radiation dose received during a micro-CT examination may have adverse effects on living subjects.
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